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The relationship between anaesthetic technique and graft patency after open lower limb revascularization is unclear. The aim of this study was to evaluate the association between 30-day graft patency after elective infrainguinal bypass and anaesthetic technique (regional anaesthesia (RA, i.e. neuraxial and/or peripheral nerve blockade) compared with general anaesthesia (GA)). Patients who underwent elective infrainguinal bypass in the 2014-2019 National Surgical Quality Improvement Program Vascular Procedure Targeted Lower Extremity Op