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On the molecular degree, c-Maf directly restrained T-bet expression. Alternatively, c-Maf expression was determined by T-bet and managed by IL-1β, IL-18 and Notch signals. Hence, we define c-Maf as an important cell-intrinsic brake into the kind 1 effector purchase which types an adverse feedback loop with T-bet to preserve the identity of CCR6- ILC3s. © 2020, Tizian et al.Distinctions between mobile types underpin organizational axioms for nervous system functio