https://www.selleckchem.com/pr....oducts/prt062607-p50
The voxel-level logistic model has an accuracy of AUC = 0.94, Brier score = 2.6x10-5. Model predictions are a threefold increased risk in the 4 mm region around the ventricular system and an LETd-dependent RBE of e.g. 1.22 for LETd = 2 keV/μm and 1.56 for LETd = 5 keV/μm. The patient-level risk model has an accuracy of AUC = 0.78, Brier score = 0.13. CONCLUSIONS Our findings present clinical evidence for an increased risk in ventricular proximity and for a proton RBE that increases significantly with increasing LET. We pre
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