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A recommended screening strategy for RTT is to first look for mutations in exons 3 and 4 of MECP2, followed by exons 1 and 2, testing for large deletions in MECP2, and screening for mutations in genes, such as CDKL5 and FOXG1 that are reported to cause a Rett-like phenotype. There is a strong need to identify simple and cost-effective biomarkers for multiple sclerosis (MS). To evaluate the serum levels of receptor for advanced glycation end products (RAGE) ligand, the high-mobility group box (HMG 1 and its correlation with changes in