https://www.selleckchem.com/pr....oducts/ch4987655.htm
We used native chemical ligation (NCL) to synthesize a 2'-O-N-[N-(S-tert-butylthiocysteinyl)aminobutyl]carbamoylethyl (CysBCE) ribothymidine-derived oligonucleotide to expand the variety of peptide conjugation sites, allowing the incorporation of peptides at the 2'-hydroxy group when the oligonucleotide forms a duplex with the complementary strand. The NCL reaction with a peptide thioester and the modified oligonucleotide proceeded smoothly even when the CysBCE modification was in the middle of the oligonucleotide sequence. In additio
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