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All rats had been later divided into regular control group, model group and ATZ (25, 50, 75 mg/kg) group arbitrarily. Biochemical variables including body weight, renal index, blood glucose, 24 h UAER, Scr, BUN, T-SOD, GSH-Px and MDA had been comprehensively determined after 8-week successive administrations. HE and PAS stainings were done to observe the histopathological modifications of kidney. Western blot was performed to detect the expressions of TGF-β1, Nrf2, HQ-1 and NQO1. Key re
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