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We present a series of three kidney transplant patients developing epidermoid cysts after receiving oral tacrolimus for long-term prevention of rejection of the allograft. Cyclosporin A has been known to show this cutaneous adverse drug reaction, but this is the first series of patients with epidermoid cysts following tacrolimus to the best of our knowledge. © 2020 Wiley Periodicals, Inc.The use of the tetrabutylammonium additive was investigated in the ultra-high performance reversed-phase liquid chromatographic elution of basic mole