https://arq621inhibitor.com/mi....crostructural-charac
We identified 46 de novo AML-RUNX1mut patients [32 (70%) men, 14 (30%) females; median age, 66.5 years] with 54 RUNX1 mutations [median VAF, 32% (2-97%)]. Aim mutations clustered in the runt-homology-domain and frame-shift mutations inside the transactivation domain. Compared to AML-RUNX1wt, AML-RUNX1mut showed male predominance (p = 0.02), greater regularity of SRSF2 (p = 0.02), and ASXL1 (p = 0.0004) mutations and regular karyotype (p = 0.01), and absent NPM1 mutations (p = 0.0002
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