https://www.selleckchem.com/pr....oducts/1-phenyl-2-th
Male SPARC-null mice expressed less aggrecan mRNA than wild-type controls. After 6months of running, collagen, , and expression was increased in male and was increased in female SPARC-null mice. Sex differences were observed in wild-type mice and in response to IDD and long-term running. Voluntary running results in changes in mRNA consistent with increased ECM turnover and disc regeneration. Improved disc ECM might contribute to the beneficial effects of exercise on LBP and may create an intradiscal environment hospitable t
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