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In contrast, neutral pH significantly exaggerates the flexibility of the protein with bound CLR that causes a partial exposure of the ligand to the water phase and its mislocation inside the ligand-binding pocket, which might obstruct CLR translocation through the membrane.In this study, the pressure drop obtained from physical experiments and theoretical approaches of a single horizontal wellbore is reviewed and a comprehensive wellbore pressure-drop model is derived for a multibranch well. We propose a new coupling model for fluid fl
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