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Pioglitazone, an FDA approved element, has shown neuroprotective properties after TBI and SCI, nevertheless the underlying mechanism(s) tend to be unidentified. We hypothesized that the discussion between pioglitazone and a novel mitochondrial protein labeled as mitoNEET had been the foundation for neuroprotection after CNS injury. We discovered that mitoNEET is a vital mediator of Ca2+-mediated mitochondrial dysfunction and program that binding mitoNEET with