https://www.selleckchem.com/pr....oducts/elacestrant.h
Subtypes, WHO grade and tumor budding profoundly impacted all survival parameters (P less then 0.001 for all analyses), with CRC subtypes and tumor budding-but not WHO grade-being stage-independent prognosticators for all survival comparisons. WHO grade had very limited prognostic value in CRC subtypes, while tumor budding retained its strong prognostic impact in most scenarios. Accurate delineation of CRC subtypes introduced in the 2019 WHO classification provides strong stage-independent prognostic information, arguing that they s