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And accordingly, the frequencies of regulatory CD8+ CD25+ T cells were also found significantly increased in these patients. Collectively, the results suggest that regulatory CD4+ and CD8+ T cells may play distinct roles in the pathogenesis of COVID-19. Moreover, the data indicate that NK cells might contribute to the COVID-19 associated lymphopenia. This paper describes the development and summarizes the content of a competence framework for delivery of cognitive analytic therapy (CAT). The framework was developed using the evidence-ba