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The antifungal resistence of oral candidiasis is a serious clinical issue. The in vivo efficacy of farnesol combined with antifungals for oral candidiasis remain unknow. The possible therapeuticeffects of a combination of farnesol and antifungal drugs and the regulation of inflammatorycytokines in murine oral candidiasis were investigated in this study. An experimental oral candidiasis model was constructed using ICR mice. Farnesol at 25 and 50 lM did not change IL-17,IFN-γ and TNF-α production during oral candidiasis compared with that