Causes of Truck Crash Accidents While the driver of the truck is usually at fault for the truck crash however, there are other factors that could cause an accident. Driver fatigue, impaired driving and trucks that carry dangerous cargo are some of the most frequently cited causes of truck accidents. Companies that produce such equipment could also be held accountable for damages. In any event medical attention should be sought out as soon as is possible, and you must see your primary healthcare physician in case you have injuries. Keep a deta