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Collectively, these results suggested that pulvones A and C's anti inflammatory impacts had been highly relevant to the interruption of NF-κB activation by inhibiting IKKβ kinase. The phytochemical examination of Andrographis paniculata resulted in the separation of a novel 15-spiro diterpenoid dimer bisandrographolide G (1). Its structure had been determined by 1D and 2D NMR, HRESIMS, digital circular dichroism (ECD), and TD DFT computations of ECD spectra. It showed potent inhibitory a

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