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In particular, when expressed together, Grd and Lcch3 form a non-selective cationic channel that opens at low concentrations of GABA and with sensitivity to insecticides similar to that of homomeric Rdl channels. Conclusion and implications For off-target species like the honeybee, the chronic sublethal exposure to insecticides constitutes a major threat. At these concentration ranges, our work points out that homomeric RDL receptors may not be the most pertinent target to study and others GABA receptor subtypes should be considered in
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