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These compounds exhibited significant activity against NDM-1, with IC50 values 0.06-0.94 μM. In vitro, compounds 6k and 6n could restore the game of meropenem against Klebsiella pneumoniae, Escherichia coli and Proteus mirabilis having either NDM or IMP. In specific, the activity of meropenem against E. coli making NDM-4 could be improved as much as 5333 instances when these two compounds were used. Time-kill cell-bas