https://www.selleckchem.com/pr....oducts/halofuginone.
A rhodium/chiral diene catalytic system is reported for the reaction of enone-diones and arylboronic acids that allows the switchable synthesis of chiral bicyclic products and acyclic products in a controlled manner. The production of bicyclic products containing four contiguous stereocenters is assumed to proceed through the enantioselective arylrhodation of enone-diones with Cs2CO3, forming a rhodium-enolate intermediate, followed by desymmetrization of the diastereotopic diones via aldol cyclization with quantitative diastereose
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