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in the manifestations of IIM.INTRODUCTION Alkaptonuria (AKU) is a rare metabolic disease. The global incidence is 1100,000 to 1250,000. However, identification of a founder mutation in a gypsy population from India prompted us to study the prevalence of AKU in this population and to do molecular typing in referred cases of AKU from the rest of India. OBJECTIVE To determine the prevalence of AKU in the gypsy population predominantly residing in the seven districts of Tamil Nadu. To determine the molecular characteristic of AKU cases ref
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