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Our work provides a new insight into 3D-μPAD design with enclosed channels, which redefines the methodology in 3D printing.Heritable Connective Tissue Disorders (HCTD) show an overlap in the physical features that can evolve in childhood. It is unclear to what extent children with HCTD experience burden of disease. This study aims to quantify fatigue, pain, disability and general health with standardized validated questionnaires. This observational, multicenter study included 107 children, aged 4-18 years, with Marfan syndrome (MFS), 58%
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