https://www.selleckchem.com/pr....oducts/SB-203580.htm
tuberculosis likely contributing to a reduction in glycolytic flux. The generation of endogenous reactive oxygen species at acidic pH is consistent with the inhibition of GAPDH, an enzyme well-known to be sensitive to oxidation. This work shows that M. tuberculosis alters its carbon diet in response to pH and provides a greater understanding of the physiology of this pathogen during acid stress.During growth, cells must expand their cell volumes in coordination with biomass to control the level of cytoplasmic macromolecular crowding.
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