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45) during exercise correlated with the lowest V̇E/V̇CO2 ratio (P less then 0.05 for all). In contrast, in HFrEF, age (r=0.47) and CO (r=-0.54) during exercise, but not e' and E/e', correlated with the lowest V̇E/V̇CO2 ratio. Conclusions Loss of CO augmentation was associated with ventilatory inefficiency in HF regardless of LVEF, although lung congestion determined ventilatory efficiency only in HFpEF.Background Elderly patients admitted to hospital with heart failure (HF) often have cognitive impairment, but the association between thes