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05) by GSEA. We detected five important chemicals such as Pinosylvin (P = 0.0128), Bromobenzene (P = 0.0134), Clonidine (P = 0.0372), Gabapentin (P = 0.0372) and Melatonin (P = 0.0404) which are directly associated with insomnia. CONCLUSION Our study results provide new clues for revealing the roles of environmental chemicals in the development of insomnia. © Sleep Research Society 2020. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@o