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As such, the PROSEM affirms that design thinking is an open and adjustable concept which can be embedded and modified in various problem-solving procedures.Ordinary differential equation (ODE) models are popularly used to describe complex dynamical systems. When estimating ODE parameters from noisy data, a common distribution assumption is using the Gaussian distribution. It is known that the Gaussian distribution is not robust when abnormal data exist. In this article, we develop a hierarchical semiparametric mixed-effects ODE model fo
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