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DTSSP NPs with a 71 CP ratio and 21 XP ratio were further characterized by stability in the presence proteases and reducing agents. DTSSP NPs fully encapsulated the model protein and displayed 81% protein release when incubated with 5 mM dithiothreitol for twelve hours. This work contributes to understanding stimulus-responsive crosslinking of polymeric nanoparticles and could be foundational to clinical administration of therapeutic proteins. This article is protected by copyright. All rights reserved. This article is protected by copyri
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