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88; p0.001). Overall, greatest comfort was observed for HFNC flows between 30 and 40L/min but with individual variability. Measuring mean inspiratory flow during an SBT allows for individualised setting of HFNC flow rate immediately post-extubation and achieves the greatest comfort and interface tolerance. Measuring mean inspiratory flow during an SBT allows for individualised setting of HFNC flow rate immediately post-extubation and achieves the greatest comfort and interface tolerance. The number of hospitalized immunosuppressed adul