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Hence, MSC-EVs may be used as a novel substitute for MSC-based treatment in sepsis. Here, we summarize the properties and applications of MSC-EVs in sepsis. Copyright © 2020 Cheng, Cao and Qin.IRF-7 mediates robust creation of type I IFN via MyD88 associated with the TLR9 path in plasmacytoid dendritic cells (pDCs). Earlier in vitro studies using bone marrow-derived dendritic cells lacking either Irf7 or Irf3 have actually demonstrated that only IRF-3 is needed for IFN
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