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cture and chemistry of solid-electrolyte interphases, cathode-electrolyte interphase, and electrode materials in batteries to reflect how cryo-EM could inspire rational materials design and guide battery research toward practical applications. We then discuss how cryo-EM helped to reveal guest intercalation chemistry in weakly bonded metal-organic-frameworks to develop a complete picture of host-guest interaction. Next, we summarize efforts in hybrid perovskite materials for solar cells where cryo-EM preserved the volatile organic mole