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The ecosystem and water quality of Terme River, an essential drinking and irrigation water source in the region, are at risk due to anthropogenic pressures. Therefore, the present study aim to present a comprehensive overview of the water quality state and pollution sources of the river. Some physicochemical water quality parameters were analyzed by standard methods along the surface water of river spatiotemporally. The concentrations of major elements and heavy metals (Na, Mg, K, Ca, Al, Cr, Fe, Co, Mn, Ni, Zn, Cd, Cu, Pb, As) were measure