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© The Author(s) 2019.The brain, spinal cord and retina are protected from blood-borne compounds by the blood-brain barrier (BB, blood-spinal cord barrier (BSC and blood-retina barrier (BR respectively, which create a physical interface that tightly controls molecular and cellular transport. The mechanical and functional integrity of these unique structures between blood vessels and nervous tissues is critical for maintaining organ homeostasis. To preserve the stability of these barriers, interplay between constituent barrier cel