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The present results indicate that the natural antisense RNA PEBP1P3 regulated the alternative splicing of CD45 RNA, and that might be correlated with the regulation of histone modification and DNA methylation.We analytically and numerically show that the Hillery-Zubairy's entanglement criterion is satisfied both below and above the threshold of coupled non-degenerate optical parametric oscillators (NOPOs) with strong nonlinear gain saturation and dissipative linear coupling. We investigated two cases for large pump mode dissipation, bel