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Because of the rarity of PJS, this come together with earlier researches, have shown the significance of LKB1 promoter methylation in PJS development and prognosis.The promoter methylation degree of LKB1 gene in PJS polyps is usually elevated compared to normal colon mucosa. Yet not every one of PJS polyps carry hypermethylated LKB1 promoter. Hypomethylation in this region features linked to malignant tumors in PJS patients. Given the rareness of PJS, this work together with earli

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