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The Three Gorges area strongly contributes to the increase in ion loading in the TGR due to enhanced water and rock interactions in comparison with the period before TGD operation. © 2020 Published by Elsevier Ltd.Objective Previous human and animal studies have shown that excessive maternal intake of folic acid (FA) predisposes to impaired glucose tolerance in the offspring. However, the underlying mechanism is unknown. Therefore, we aimed to determine whether excessive supplementation with FA during pregnancy affects the glucose tol