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This study aimed to quantify the health and productivity burden of migraines in Australia, measured by quality-adjusted life years (QALYs), productivity-adjusted life years (PALYs, a novel measure of productivity), and associated health-care and broader economic costs. A Markov state-transition model was constructed to simulate follow-up of Australians aged 20-64years over the next 10years. The model was first run using current prevalence estimates of migraine. It was then rerun assuming that people with migraine hypothetically did not ha