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Roux-en-Y gastric bypass (RYG is the most effective treatment for type 2 diabetes mellitus (T2DM). Previous studies have reported that silent information regulator 1 (Sirt1) closely relates to many pathological processes of glucose metabolism and insulin resistance (IR). However, it is unclear whether Sirt1 is involved in the hepatic glucose metabolism of T2DM after RYGB. T2DM rats were randomly divided into four groups Control, DM, Diet and RYGB. Normal rats were served as the control group. Hematoxylin and eosin (HE) staining an
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