What Causes Trucking Accidents? Trucks are only a small percentage of the vehicles on the road but they can be a source of serious injury or death. Accidents involving large trucks may occur when drivers are distracted or fail to watch their blind spots. Driver fatigue is also a factor in trucking accidents. These drivers work all day long, with no breaks in order to meet their targets. Driver Error Driver error is the primary cause of trucking accidents, and it is a very serious problem. There are that could contribute to driver errors and i