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Loaded walking with a rucksack results in both gravitational and inertial forces of the load that must be borne by human carriers. The inertial force may be the source of metabolic burden and musculoskeletal injuries. This paper presents a lightweight backpack with a disturbance observer-based acceleration control to minimize the inertial force. The backpack was evaluated by seven participants walking on a treadmill at 5 km h-1 with a 19.4 kg load. Three experimental conditions were involved, including walking with a locked load (LOCKE