https://www.selleckchem.com/pr....oducts/pi3k-hdac-inh
54 ± 6.67μM and 27.58 ± 3.97μM) in vitro in a concentration-dependent manner. After co-feeding with scutellarin, the AUC and C of rosuvastatin in rats increased to 27.4% and 37.7%, respectively. The t and t of rosuvastatin showed no significant change. Moreover, scutellarin caused 29.2% and 28.1% decrease in the CL and CL/F of rosuvastatin. Scutellarin may inhibit the hOATP1B3- and rOATP1B2-mediated transport of rosuvastatin in vitro, and exerts a moderate inhibitory effect on the pharmacokinetics of rosuvastatin in rats.
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