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How this might be incorporated in what one may envision as TBL is discussed.Introduction Pulmonary drug delivery is a complex field of research combining physics which drive aerosol transport and deposition and biology which underpins efficacy and toxicity of inhaled drugs. A myriad of preclinical methods, ranging from in-silico to in-vitro, ex-vivo and in-vivo, can be implemented.Areas covered The present review covers in-silico mathematical and computational fluid dynamics modelization of aerosol deposition, cascade impactor technology