https://www.selleckchem.com/pr....oducts/FK-506-(Tacro
RESULTS We identified a homozygous frameshift mutation in TNFSF13, the gene encoding APRIL, in the patient. APRIL mRNA and protein were completely absent in the monocytes and iPS-moDCs of the patient. In contrast to previous animal model studies, the patient showed hypogammaglobulinemia with markedly reduced plasmacytes in peripheral blood and clearly increased circulating marginal zone B cells. Although iPS-moDC-induced in vitro plasmacyte differentiation was reduced in the patient, recombinant APRIL supplementation correct
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