https://dmxaachemical.com/mex3....a-leads-to-improveme
The pan-bromodomain and extra-terminal domain (BET) inhibitor, (+)-JQ1 (1), was reported to prevent angiogenesis. Nevertheless, due to the non-selectivity activity of (+)-JQ1 towards all BET family unit members, the part of BRD4 and therefore of the bromodomains (BD1 and BD2) in angiogenesis remains elusive. Herein, we identified a potent BRD4 inhibitor, ZL0513 (7), which exhibited considerable anti-angiogenic effects in chick embryo chorioallantoic membrane (CAM) and yolk sac
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