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Finally, we infer the dosage sensitivity of genes and non-coding elements, revealing trends related to element class and conservation. This work will help guide SV analysis and interpretation in the era of WGS.The emergence of the coronavirus disease 2019 (COVID-19) heralded a new era in the cross-species transmission of severe respiratory illness leading to rapid spread in mainland China and around the world with a case fatality rate of 2.3% in China and 1.8-7.2% outside China (Wu McGoogan, 2019; Centers for Disease Control and