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To investigate associations between adverse changes in employment status and physical and mental health among US adults (more than or equal to 18 years) during the COVID-19 pandemic. Data from participants (N = 2565) of a national Internet panel (June 202 were assessed using path analyses to test associations between changes in self-reported employment status and hours worked and physical and mental health outcomes. Respondents who lost a job after March 1, 2020 (vs those who did not) reported more than twice the number of mentally