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Moreover, a meta-analysis was conducted to obtain the risk ratios (RRs) and 95% CIs by adopting random-effects models. The major outcome was the incidence of ischemic stroke/TIA in adults with and without tooth loss. On the whole, four cohort studies and three case-control studies were covered, which involved 4,625,514 participants with 33,088 ischemic stroke/TIA cases. In cohort (adjusted RR = 2.58, 95% CI 2.39-2.79, P less then 0.00001, I 2 = 31%) and case-control studies (adjusted MD = -4.15, 95% CI -6.09-(-2.22), P less then 0.001, I 2