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The new deep neuro-fuzzy system consists of a deep structure in the rule layer and novel architecture in the fuzzifier layer. The proposed self-organizing deep neuro-fuzzy system can help us to overcome the main obstacles in the field of neuro-fuzzy system applications, such as the curse of dimensionality. The goal of this paper is to illustrate that the neuro-fuzzy system can very useful in high dimensional data, such as genomics data, using the proposed deep neuro-fuzzy system. The obtained results illustrated that our proposed method