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HIGHLIGHTS CircRNA_3079 is an abundant and stable circular RNA expressed in different tissues and cells in chicken. The circularization of circRNA_3079 does not depend on the reverse complementary repetitive sequence of the flanking sequence. CircRNA_3079 may indirectly regulate the ALV-J infection process.Detecting interacting loci pairs has been instrumental to understand disease etiology when single locus associations do not fully account for the underlying heritability. However, the number of loci to test is prohibitively large. Epis