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Four patients in the H group and 36 patients in the NH group were diagnosed with HCC after SVR. Multivariate analysis showed that male sex, age, and cirrhosis were significant risk factors for HCC incidence. There was no significant difference in the cumulative incidence of HCC after propensity-score matching adjusting for the risk factors of HCC between the two groups. Hemophilia is not a significant risk factor for hepatocarcinogenesis after SVR against HCV. Hemophilia is not a significant risk factor for hepatocarcinogenesis after SVR