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ObjectiveMenarcheal age is the starting point of reproductive life and could be a marker of health and socioeconomic status of a population.The aim of this study was to assess the temporal pattern in variability of menarcheal age from 2001 to 2019 and the relationship with biological factors and educational level of parents. Subjects and methods A cross-sectional anthropometric survey was conducted in three intervals 2001-2004, 2011-2014 and in 2019. In total, 5201 adolescent girls from Vojvodina (North Serbia) aged 11-18 were surveyed, 3272 (62.91%) of the