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Because of widespread use, understanding the pulmonary effects of cannabis use is important; but its role independent from tobacco smoking is yet to be elucidated. We used Mendelian randomization (MR) to assess the effect of genetic liability to lifetime cannabis use and cannabis use disorder on pulmonary function and lung cancer. We used four single nucleotide polymorphisms associated with lifetime cannabis use (p value 5× 10 ) from a genome-wide association study (GWAS) of 184,765 individuals of European descent from the Internationa